Statistical Physics Applied to Physiological Signals ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ H. Eugene Stanley Center for Polymer Studies and Department of Physics Boston University, Boston, MA 02215 A major problem in biology is the quantitative analysis of nonstationary time series. A central question is whether such noisy fluctuating signals contain information useful for understanding underlying physiological mechanisms. This review talk summarizes recent work that analyzes physiological signals---principally lengthy time series of interbeat heart intervals---using a range of approaches adapted from modern statistical mechanics. These approaches include (i) detrended fluctuation analysis of long-range anticorrelations, (ii) wavelet analysis, and (iii) multifractal analysis.